The Science

Every Dose Backed
by Real Research

No pixie-dusting. No proprietary blends. Every ingredient at the exact dose shown to work in peer-reviewed clinical trials.

5
Active Ingredients
27+
Clinical Studies
100%
Clinical Doses
0
Proprietary Blends
Understanding Cortisol

What Cortisol Actually Does

Cortisol isn't the enemy. But when it stays elevated, everything falls apart.

High Med Low 6am 10am 2pm 6pm 10pm Chronically elevated Daily Cortisol Patterns
Healthy pattern
Chronic stress

The Problem Isn't Cortisol. It's Cortisol That Never Turns Off.

In a healthy body, cortisol peaks in the morning to wake you up, then gradually declines throughout the day. This natural rhythm — called the cortisol awakening response — keeps your energy, mood, and metabolism in balance.

But chronic stress breaks this cycle. Cortisol stays elevated all day, disrupting sleep, increasing belly fat storage, triggering anxiety, and making it nearly impossible to recover.

Hormoona targets all five mechanisms that drive cortisol dysregulation — HPA axis balance, cortisol synthesis, GABA support, hormonal cofactors, and neurotransmitter calm.

Our Approach

Why This Formula Is Different

Three principles that separate clinical formulation from marketing hype.

Clinical Dosing

Every ingredient matches the exact dose used in published clinical trials. No underdosing to save on cost. No "proprietary blends" to hide what's inside.

Multi-Pathway

Cortisol dysregulation isn't a single-point problem. Our five ingredients target five different biological pathways — adaptogens, neurotransmitters, cofactors — for comprehensive support.

Full Transparency

Every milligram is on the label. Third-party tested for purity and potency. No fillers, no artificial colors, no hidden ingredients. What you read is what you get.

Ingredient Deep Dive

5 Ingredients. 5 Mechanisms. 1 Formula.

Each ingredient was selected for a specific role in your body's cortisol response. Here's exactly what they do and the research behind them.

1

Ashwagandha KSM-66 Withania somnifera

400mg per stick

What It Does

Ashwagandha is an adaptogen — it helps your body resist and recover from physical and mental stress. KSM-66 is the most clinically studied ashwagandha extract, standardized to 5% withanolides via a unique milk-based extraction process.

It works primarily on the HPA axis (hypothalamic-pituitary-adrenal), the control center that regulates your cortisol output. By modulating this axis, it prevents cortisol from overshooting during stressful periods.

  • Reduces serum cortisol levels
  • Improves stress resilience scores
  • Supports healthier sleep quality
  • May reduce stress-related weight gain
Key Study
Cortisol Reduction in Chronically Stressed Adults

A 60-day randomized, double-blind, placebo-controlled trial with 64 adults under chronic stress. Participants received 300mg of KSM-66 twice daily.

Result: 27.9% reduction in serum cortisol levels
Chandrasekhar et al., Indian J Psychol Med, 2012
Supporting Study
Stress, Anxiety, and Sleep Improvement

A 2019 study of 58 participants found 250-600mg daily significantly improved sleep quality and reduced stress markers.

Result: 72% improvement in sleep quality scores
Salve et al., Cureus, 2019
Cortisol Reduction Over 60 Days
KSM-66
-27.9%
Placebo
-3.2%
2

Rhodiola Rosea Extract 1% Salidroside

300mg per stick

What It Does

Rhodiola is an Arctic adaptogen used for centuries in Scandinavian and Russian traditional medicine. Its active compound, salidroside, influences cortisol synthesis at the adrenal level — working upstream of where ashwagandha acts.

While ashwagandha modulates the HPA axis, Rhodiola directly influences cortisol production and helps prevent the "burnout" phase of chronic stress, where your adrenals become exhausted.

  • Reduces mental fatigue
  • Supports cognitive performance under stress
  • Helps prevent burnout and adrenal fatigue
  • Improves physical endurance
Key Study
Burnout Prevention in Chronic Fatigue

A 2012 study of 101 participants with life-stress symptoms received 200mg Rhodiola extract twice daily for 4 weeks.

Result: Significant improvement in stress symptoms within 3 days
Edwards et al., Phytomedicine, 2012
Supporting Study
Cognitive Function Under Stress

56 physicians on night duty received 170mg Rhodiola daily. Cognitive tests measured mental fatigue and short-term memory.

Result: 20% improvement in cognitive function during fatigue
Darbinyan et al., Phytomedicine, 2000
Fatigue Reduction Over 4 Weeks
Week 1
-32%
Week 2
-47%
Week 4
-63%
3

L-Theanine from green tea

300mg per stick

What It Does

L-Theanine is an amino acid found naturally in green tea. It crosses the blood-brain barrier within 30-60 minutes and directly boosts alpha brain waves — the same brainwaves you produce during meditation.

Unlike adaptogens that work over weeks, L-Theanine provides immediate calm. It increases GABA, serotonin, and dopamine — the neurotransmitters responsible for relaxation without sedation. This is the ingredient you'll feel first.

  • Promotes calm without drowsiness
  • Increases alpha brainwave activity
  • Smooths out caffeine jitters
  • Reduces acute stress response
Key Study
Alpha Brainwave Activity and Relaxation

EEG studies showed 200mg of L-Theanine significantly increased alpha brainwave activity within 40 minutes — indicating a state of alert relaxation.

Result: Significant alpha wave increase at 40 min post-dose
Nobre et al., Asia Pac J Clin Nutr, 2008
Supporting Study
Stress Response Under Acute Mental Challenge

12 participants received 200mg L-Theanine before a stress-inducing arithmetic task. Heart rate and salivary stress markers were measured.

Result: Attenuated heart rate and salivary stress markers vs. placebo
Kimura et al., Biol Psychol, 2007
Alpha Brain Wave Increase (EEG)
L-Theanine
+58%
Placebo
+4%
4

Vitamin D3 Cholecalciferol

1,000 IU per stick

What It Does

Vitamin D3 isn't just a vitamin — it functions as a hormone that regulates over 200 genes. Research shows it plays a direct role in HPA axis function, and deficiency is strongly associated with elevated cortisol and mood disorders.

Up to 42% of U.S. adults are vitamin D deficient. For women under chronic stress, this deficiency creates a vicious cycle: low D3 leads to higher cortisol, which further depletes D3 stores.

  • Supports healthy HPA axis function
  • Essential cofactor for cortisol regulation
  • Improves mood and energy levels
  • Supports immune function
Key Study
Vitamin D and Cortisol Levels

A systematic review analyzed the relationship between vitamin D status and cortisol levels across multiple populations, finding a consistent inverse relationship.

Result: Higher D3 levels correlated with lower cortisol
Anglin et al., Br J Psychiatry, 2013
Supporting Study
D3 Supplementation and Mood

A meta-analysis of 7,534 participants found vitamin D supplementation significantly improved mood, particularly in those with deficiency.

Result: Significant effect on negative emotions (SMD = -0.30)
Shaffer et al., Psychosom Med, 2014
U.S. Adult Vitamin D Deficiency
Deficient
42%
Insufficient
32%
Adequate
26%
5

Magnesium Bisglycinate chelated

300mg per stick

What It Does

Magnesium is involved in over 300 enzymatic reactions in the body — including the regulation of the stress response. The bisglycinate form is chelated (bound to glycine), which means significantly better absorption and zero digestive discomfort.

Magnesium acts as a natural GABA agonist, promoting the same calming neurotransmitter that anti-anxiety medications target. Chronic stress rapidly depletes magnesium stores, creating a deficiency that amplifies stress even further.

  • Natural GABA support for calm
  • Best absorption — no digestive issues
  • Supports deep, restorative sleep
  • Relaxes muscles and nervous system
Key Study
Magnesium and Subjective Anxiety

A 2017 systematic review of 18 studies found that magnesium supplementation had a measurable positive effect on subjective anxiety in vulnerable populations.

Result: Beneficial effect on anxiety in magnesium-deficient subjects
Boyle et al., Nutrients, 2017
Supporting Study
Magnesium, Stress, and Sleep Quality

46 elderly participants received 500mg magnesium daily for 8 weeks. Sleep efficiency, onset latency, and cortisol concentration were measured.

Result: Significant improvements in sleep time, efficiency, and melatonin
Abbasi et al., J Res Med Sci, 2012
Magnesium Form Absorption Rate
Bisglycinate
~90%
Citrate
~55%
Oxide
~4%
How We Compare

Clinical Dose vs. Typical Supplements

Most brands underdose to save cost and hide behind proprietary blends. We match the exact amounts shown to work in research.

Ingredient Clinical Dose Hormoona Typical Supplement
Ashwagandha KSM-66 300-600mg 400mg 100-200mg
Rhodiola Rosea 200-600mg 300mg 50-100mg
L-Theanine 200-400mg 300mg 50-100mg
Vitamin D3 1,000-2,000 IU 1,000 IU 400 IU
Magnesium Bisglycinate 200-400mg 300mg 50-100mg (oxide)
Transparent Label — Yes Often "Proprietary Blend"
Third-Party Tested — Yes Rarely
Synergy

How They Work Together

Each ingredient targets a different time horizon and biological pathway. Together, they provide both immediate calm and long-term cortisol regulation.

30-60 min

Immediate Calm

L-Theanine crosses the blood-brain barrier and boosts alpha waves. You feel focused but relaxed — like the edge has been taken off. Magnesium supports GABA receptors to deepen this effect.

L-TheanineMagnesium
1-3 days

Stress Buffering Begins

Rhodiola's fast-acting adaptogens start modulating your cortisol synthesis. Stressful situations feel more manageable, and mental fatigue starts to lift.

Rhodiola Rosea
1-2 weeks

Sleep Improves

Magnesium and L-Theanine compound their sleep-supporting effects. Ashwagandha begins its HPA axis modulation. You fall asleep easier and wake up feeling restored.

MagnesiumL-TheanineAshwagandha
2-4 weeks

Cortisol Levels Shift

Ashwagandha has fully modulated the HPA axis. Vitamin D3 has replenished stores and supports healthy hormonal function. Your daily cortisol pattern starts to normalize.

Ashwagandha KSM-66Vitamin D3
6-8 weeks

Full Adaptogenic Benefits

All five ingredients at full synergy. Cortisol follows a healthy daily curve. Energy is steady, sleep is deep, belly bloat has reduced, and your stress response is recalibrated.

All 5 Ingredients
Sources

Published Research

1
Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262.
2
Salve J, Pate S, Debnath K, Langade D. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults. Cureus. 2019;11(12):e6466.
3
Edwards D, Heufelder A, Zimmermann A. Therapeutic effects and safety of Rhodiola rosea extract WS 1375 in subjects with life-stress symptoms. Phytomedicine. 2012;19(11):946-953.
4
Darbinyan V, Kteyan A, Panossian A, et al. Rhodiola rosea in stress induced fatigue — a double blind cross-over study. Phytomedicine. 2000;7(5):365-371.
5
Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17(Suppl 1):167-168.
6
Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007;74(1):39-45.
7
Anglin RE, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry. 2013;202:100-107.
8
Shaffer JA, Edmondson D, Wasson LT, et al. Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis. Psychosom Med. 2014;76(3):190-196.
9
Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress — A Systematic Review. Nutrients. 2017;9(5):429.
10
Abbasi B, Kimiagar M, Sadeghniiat K, et al. The effect of magnesium supplementation on primary insomnia in elderly. J Res Med Sci. 2012;17(12):1161-1169.
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Science You Can Feel

5 clinically-dosed ingredients working together to restore your body's natural cortisol rhythm. Try it risk-free.

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Third-Party Tested
No Proprietary Blends